Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus (Q39776237)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19905033%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus (English)

1 reference

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12 February 2020

1 reference

2

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Robert A Lamb

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Lawrence H Pinto

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author name string

Victoria Balannik

1

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Yuki Ohigashi

3

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12 February 2020

Xianghong Jing

4

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Emma Magavern

5

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12 February 2020

William F Degrado

7

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12 February 2020

language of work or name

English

0 references

publication date

1 December 2009

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12 February 2020

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volume

48

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12 February 2020

page(s)

11872-11882

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12 February 2020

issue

50

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Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance.

12 February 2020

cites work

1 reference

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Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

In vivo and in vitro alterations in influenza A/H3N2 virus M2 and hemagglutinin genes: effect of passage in MDCK-SIAT1 cells and conventional MDCK cells

22 September 2017

1 reference

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Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Structural basis for the function and inhibition of an influenza virus proton channel

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Structure and mechanism of the M2 proton channel of influenza A virus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

The oligomeric state of the active BM2 ion channel protein of influenza B virus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Proton transport behavior through the influenza A M2 channel: insights from molecular simulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Controlling influenza virus replication by inhibiting its proton channel

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Anti-influenza virus agents: synthesis and mode of action

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

The M2 proton channels of influenza A and B viruses

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Frequency of Amantadine-Resistant Influenza A Viruses during Two Seasons Featuring Cocirculation of H1N1 and H3N2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

22 September 2017

1 reference

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Ion selectivity and activation of the M2 ion channel of influenza virus

22 September 2017

1 reference

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Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

22 September 2017

1 reference

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Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

The molecular basis of the specific anti-influenza action of amantadine

22 September 2017

1 reference

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Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States

22 September 2017

1 reference

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Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function

20 August 2018

1 reference

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Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

Neutron diffraction reveals the site of amantadine blockade in the influenza A M2 ion channel.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794939

20 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19905033

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12 December 2020

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Identifiers

DOI

10.1021/BI9014488

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19905033%20AND%20SRC:MED&resulttype=core&format=json

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12 February 2020

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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12 February 2020

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