A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols (Q39776402)

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English	A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols	scientific article

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scholarly article

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Europe PubMed Central

14 September 2017

A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols (English)

1 reference

Europe PubMed Central

14 September 2017

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author name string

Haowei Song

1

1 reference

Europe PubMed Central

14 September 2017

Sasanka Ramanadham

2

1 reference

Europe PubMed Central

14 September 2017

Shunzhong Bao

3

1 reference

Europe PubMed Central

14 September 2017

Fong-Fu Hsu

4

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Europe PubMed Central

14 September 2017

John Turk

5

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Europe PubMed Central

14 September 2017

language of work or name

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publication date

1 January 2006

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Europe PubMed Central

14 September 2017

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Europe PubMed Central

14 September 2017

45

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Europe PubMed Central

14 September 2017

3

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Europe PubMed Central

14 September 2017

1061-1073

1 reference

Europe PubMed Central

14 September 2017

Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages

1 reference

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Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}

1 reference

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Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS

1 reference

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Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets

1 reference

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Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests

1 reference

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Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

1 reference

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Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells

1 reference

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Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells

1 reference

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Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta

1 reference

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T cell chemotaxis to lysophosphatidylcholine through the G2A receptor.

1 reference

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Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript

1 reference

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Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2.

1 reference

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Human neuropathy target esterase catalyzes hydrolysis of membrane lipids

1 reference

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Structural and evolutionary relationships among protein tyrosine phosphatase domains

1 reference

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The molecular biology of the group VIA Ca2+-independent phospholipase A2.

1 reference

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22 September 2017

Arachidonic acid as a bioactive molecule

1 reference

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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

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A novel intracellular membrane-bound calcium-independent phospholipase A(2)

1 reference

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The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)

1 reference

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Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

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22 September 2017

Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2.

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22 September 2017

Molecular characterization of cytosolic phospholipase A2-beta

1 reference

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22 September 2017

Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) [etc.]

1 reference

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22 September 2017

Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

1 reference

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A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

1 reference

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

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Cloning and expression of a group IV cytosolic Ca2+-dependent phospholipase A2 from rat pancreatic islets. Comparison of the expressed activity with that of an islet group VI cytosolic Ca2+-independent phospholipase A2.

1 reference

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22 September 2017

Type IB secretory phospholipase A2 is contained in insulin secretory granules of pancreatic islet beta-cells and is co-secreted with insulin from glucose-stimulated islets

1 reference

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Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

22 September 2017

A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

22 September 2017

Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages

1 reference

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22 September 2017

Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammali

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Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways

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25 September 2017

Alternate substrate inhibitors of an alpha-chymotrypsin: enantioselective interaction of aryl-substituted enol lactones

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25 September 2017

Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

17 June 2018

Function and inhibition of intracellular calcium-independent phospholipase A2.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

17 June 2018

Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

17 June 2018

Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

17 June 2018

Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

17 June 2018

Halo enol lactones: studies on the mechanism of inactivation of alpha-chymotrypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2065752

17 June 2018

Complex transcriptional and translational regulation of iPLAgamma resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization.

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20 August 2018

A novel mechanism for the store-operated calcium influx pathway

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Identification of hepatic peroxisomal phospholipase A(2) and characterization of arachidonic acid-containing choline glycerophospholipids in hepatic peroxisomes

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20 August 2018

Calcium-Independent Phospholipase A2 Is Required for Lysozyme Secretion in U937 Promonocytes

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20 August 2018

Calcium-independent phospholipase A(2) mediates CREB phosphorylation and c-fos expression during ischemia

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20 August 2018

Structural and functional consequences of haloenol lactone inactivation of murine and human glutathione S-transferase

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20 August 2018

Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin.

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20 August 2018

Arachidonate related lipid mediators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mass spectrometric evidence that agents that cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ concentr

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose decreases Na+,K+-ATPase activity in pancreatic beta-cells. An effect mediated via Ca2+-independent phospholipase A2 and protein kinase C-dependent phosphorylation of the alpha-subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular responses to excess phospholipid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Proteolytic fragment of type IVA cytosolic phospholipase A2alpha inhibits stimulus-induced arachidonate release, whereas that of type VI Ca2+-inde

1 reference

https://pubmed.ncbi.nlm.nih.gov/16411783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI052065Q

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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