Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains. (Q39782948)

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22 January 2020

title

Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains (English)

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22 January 2020

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1 reference

Charles Warren Olanow

8

object named as

C Warren Olanow

2 references

PubMed publication ID

21322017

14 September 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21322017%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

10

Jeffrey H Kordower

2 references

PubMed publication ID

21322017

14 September 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21322017%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

9

Elliott J Mufson

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22 January 2020

author name string

Raymond T Bartus

1

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22 January 2020

Christopher D Herzog

2

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22 January 2020

Yaping Chu

3

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22 January 2020

Alistair Wilson

4

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22 January 2020

Lamar Brown

5

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22 January 2020

Joao Siffert

6

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Eugene M Johnson

7

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22 January 2020

language of work or name

English

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publication date

18 November 2010

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22 January 2020

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22 January 2020

volume

26

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issue

1

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22 January 2020

page(s)

27-36

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Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons

22 January 2020

cites work

1 reference

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

21 January 2018

1 reference

Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.

21 January 2018

1 reference

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

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Point source concentration of GDNF may explain failure of phase II clinical trial

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Crossroads in GDNF therapy for Parkinson's disease

21 January 2018

1 reference

AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease

21 January 2018

1 reference

Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease

21 January 2018

1 reference

Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys

21 January 2018

1 reference

Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum

21 January 2018

1 reference

Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease

21 January 2018

1 reference

Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point

21 January 2018

1 reference

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

21 January 2018

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Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

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Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

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Localized striatal delivery of GDNF as a treatment for Parkinson disease

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Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease

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Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects

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Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys

21 January 2018

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Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

21 January 2018

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Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor

21 January 2018

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Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Physostigmine and Recent Memory: Effects in Young and Aged Nonhuman Primates

21 January 2018

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Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

21 January 2018

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Axonal transport defects: a common theme in neurodegenerative diseases

21 January 2018

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Axonal transport defects in neurodegenerative diseases

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Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21322017

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21322017

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21322017

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/MDS.23442

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21322017%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21322017%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

21322017

1 reference