Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. (Q39796996)

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scientific article published on January 1998

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English	Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.	scientific article published on January 1998

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30 August 2019

Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene (English)

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Pietro Di Lucia

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D'Ambrosio D

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Cippitelli M

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Cocciolo MG

3

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Mazzeo D

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Lang R

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Sinigaglia F

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Panina-Bordignon P

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1 January 1998

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Journal of Clinical Investigation

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1

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30 August 2019

Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.

1 reference

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

1 reference

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High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

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1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

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Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer

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Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes

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Interleukin 12 at the site of disease in tuberculosis

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Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

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Structure-function relationships in the vitamin D endocrine system

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Immunomodulatory actions of 1,25-dihydroxyvitamin D3.

1 reference

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Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor

1 reference

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Regulation of interleukin 12 p40 expression through an NF-kappa B half-site

1 reference

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The role of IL-12 in the induction of organ-specific autoimmune diseases

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22 September 2017

Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.

1 reference

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

1 reference

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Vitamin D: recent advances

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Firefly luciferase gene: structure and expression in mammalian cells

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22 September 2017

1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes

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22 September 2017

Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA

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1 alpha,25(OH)2 vitamin D3: a steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms

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Cloning and expression of full-length cDNA encoding human vitamin D receptor

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Gene regulation by steroid hormones

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

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22 September 2017

1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis

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22 September 2017

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

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22 September 2017

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

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22 September 2017

IL-12: initiation cytokine for cell-mediated immunity

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Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.

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25 September 2017

Molecular cloning and characterization of murine IL-12 genes.

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

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Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

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1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice

1 reference

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Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.

1 reference

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In vivo beneficial effects of cyclosporin A and 1,25-dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

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1,25-Dihydroxyvitamin D3 induces normal mononuclear blood cells to differentiate in the direction of monocyte-macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of human monocyte to macrophage maturation in vitro by 1,25-dihydroxyvitamin D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-Dihydroxyvitamin D3 attenuates the expression of experimental murine lupus of MRL/l mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two nuclear signalling pathways for vitamin D

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between retinoic acid and vitamin D signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial prevention of active Heymann nephritis by 1 alpha, 25 dihydroxyvitamin D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method of obtaining monocytes in suspension

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability

1 reference

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12 December 2020

based on heuristic

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Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional control of MHC class II gene expression during differentiation from B cells to plasma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-gamma-stimulated normal human bone marrow and alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of human monocyte HLA-DR and CD4 antigen expression, and antigen presentation by 1,25-dihydroxyvitamin D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9421488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI1050

1 reference

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30 August 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9421488%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9421488%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

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