MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines (Q39800997)

14 September 2017

MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines (English)

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pancreatic adenocarcinoma

14 September 2017

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4

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14 September 2017

Mario Dandrea

1

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14 September 2017

Massimo Donadelli

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2

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14 September 2017

Chiara Costanzo

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3

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14 September 2017

Marta Palmieri

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5

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14 September 2017

language of work or name

English

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publication date

10 September 2009

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14 September 2017

Nucleic Acids Research

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14 September 2017

37

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14 September 2017

20

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14 September 2017

6681-6690

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describes a project that uses

14 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2777443/fullTextXML

inferred from PubMed Central ID database lookup

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IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells

22 September 2017

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DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

22 September 2017

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The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

22 September 2017

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22 September 2017

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Binding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Interleukin-6 repression is associated with a distinctive chromatin structure of the gene

22 September 2017

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Interaction of the nuclear protein CBF1 with the kappaB site of the IL-6 gene promoter

22 September 2017

1 reference

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

22 September 2017

1 reference

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Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor

22 September 2017

1 reference

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

22 September 2017

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The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression

22 September 2017

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22 September 2017

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Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines

22 September 2017

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NF-IL6 and NF-kappa B in cytokine gene regulation

25 September 2017

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Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

17 June 2018

1 reference

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Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway

20 August 2018

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Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells.

20 August 2018

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Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.

20 August 2018

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The kappa B enhancer of the human interleukin-6 promoter is necessary and sufficient to confer an IL-1 beta and TNF-alpha response in transfected human cell lines: requirement for members of the C/EBP family for activity

20 August 2018

1 reference

12 December 2020

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

1 reference

12 December 2020

Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma

1 reference

12 December 2020

Repression of the IL-6 gene is associated with hypermethylation

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKP723

1 reference

14 September 2017

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14 September 2017

PubMed publication ID

19745053

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