Effect of food and gemfibrozil on the pharmacokinetics of the novel prolyl hydroxylase inhibitor GSK1278863. (Q39810440)

14 September 2017

title

Effect of food and gemfibrozil on the pharmacokinetics of the novel prolyl hydroxylase inhibitor GSK1278863. (English)

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14 September 2017

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Brendan M Johnson

1

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14 September 2017

Brendt A Stier

series ordinal

2

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14 September 2017

Stephen Caltabiano

series ordinal

3

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14 September 2017

publication date

22 October 2013

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Clinical pharmacology in drug development

14 September 2017

published in

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14 September 2017

volume

3

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14 September 2017

issue

2

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14 September 2017

page(s)

109-117

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Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

14 September 2017

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

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Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

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Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone

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Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast

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Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

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Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

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The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

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Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs

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Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively

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The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.

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Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency

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7 January 2021

Role of hypoxia in the pathogenesis of renal disease

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Statistical analysis of bioavailability studies: parametric and nonparametric confidence intervals

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Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

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Identifiers

DOI

10.1002/CPDD.83

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14 September 2017

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