HIF prolyl hydroxylase inhibitors for anemia (Q28307377)

Expert Opinion on Investigational Drugs

Europe PubMed Central

title

HIF prolyl hydroxylase inhibitors for anemia (English)

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author name string

Eugene Muchnik

series ordinal

1

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Joshua Kaplan

series ordinal

2

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language of work or name

English

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publication date

May 2011

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published in

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volume

20

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page(s)

645-56

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issue

5

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cites work

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

21 April 2017

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 April 2017

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Acute postnatal ablation of Hif-2alpha results in anemia

21 April 2017

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HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

21 April 2017

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Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline

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A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

21 April 2017

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 April 2017

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

21 April 2017

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 April 2017

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

21 April 2017

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 April 2017

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 April 2017

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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

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Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

21 April 2017

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Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

21 April 2017

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

21 April 2017

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Normalization of hemoglobin level in patients with chronic kidney disease and anemia

21 April 2017

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Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

21 April 2017

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Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

21 April 2017

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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

21 April 2017

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 April 2017

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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

21 April 2017

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 April 2017

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Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion

21 January 2018

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HIF-1 and HIF-2: working alone or together in hypoxia?

21 January 2018

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

21 January 2018

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Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

21 January 2018

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Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

21 January 2018

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Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Erythrocytosis associated with a novel missense mutation in the HIF2A gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

21 January 2018

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The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Regulation of ferrochelatase gene expression by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

The human oxygen sensing machinery and its manipulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Selective inhibition of factor inhibiting hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Hyperviscosity in polycythemia vera and other red cell abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Endothelial activation markers in anemic non-dialysis chronic kidney disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Erythropoiesis stimulatory agent- resistant anemia in dialysis patients: review of causes and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Erythropoiesis-stimulating agent hyporesponsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Iron homeostasis and its interaction with prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

The role of hypoxia-inducible factors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

PHD2 in tumour angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

The role of hypoxia-inducible factors in tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Breast cancer SRC activity: bad to the bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

HIF activation protects from acute kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Angiotensin II Type 1 Receptor Blockade Inhibits the Development and Progression of HIV-Associated Nephropathy in a Mouse Model

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2011.566861

Ischemic Pre-conditioning in Deceased Donor Liver Transplantation: A Prospective Randomized Clinical Trial

21 January 2018

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10.1517/13543784.2011.566861

21 January 2018

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2676710

OpenCitations bibliographic resource ID

2676710

1 reference