Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells (Q39834604)

15 September 2017

Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells (English)

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15 September 2017

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Jürgen Schölmerich

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author name string

Hella Wobser

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15 September 2017

Christoph Dorn

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Thomas Amann

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Cornelius Bollheimer

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Roland Büttner

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Claus Hellerbrand

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15 September 2017

1 August 2009

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15 September 2017

996-1005

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https://scigraph.springernature.com/pub.10.1038/cr.2009.73

15 September 2017

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Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis

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In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

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Mitochondrial abnormalities in non-alcoholic steatohepatitis

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Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise

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Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications

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Intracellular pathways of protein synthesis and secretion in the hepatocyte

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Increases in serum unbound free fatty acid levels following coronary angioplasty

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Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans.

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Immortal activated human hepatic stellate cells generated by ectopic telomerase expression

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Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype

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Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C.

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Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis

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Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat.

21 January 2018

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The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo

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Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis

21 January 2018

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Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

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Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats.

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Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis

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Growth arrest and decrease of alpha-SMA and type I collagen expression by palmitic acid in the rat hepatic stellate cell line PAV-1.

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Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E.

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Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.

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A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease

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The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma

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Reduced expression of CYLD in human colon and hepatocellular carcinomas

21 January 2018

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PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

21 January 2018

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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

21 January 2018

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Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells

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Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis

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Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis

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7 January 2021

Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

https://api.crossref.org/works/10.1038%2FCR.2009.73

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7 January 2021

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.

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https://api.crossref.org/works/10.1038%2FCR.2009.73

7 January 2021

Identifiers

DOI

10.1038/CR.2009.73

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15 September 2017

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