Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity. (Q39855660)

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27 January 2020

title

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity (English)

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27 January 2020

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4

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27 January 2020

M Scott

5

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27 January 2020

author name string

M Walker

1

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27 January 2020

E J Black

2

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27 January 2020

V Oehler

3

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27 January 2020

language of work or name

English

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publication date

4 May 2009

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27 January 2020

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27 January 2020

volume

28

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27 January 2020

issue

24

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27 January 2020

page(s)

2314-2323

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https://scigraph.springernature.com/pub.10.1038/onc.2009.102

27 January 2020

exact match

0 references

cites work

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

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Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

22 September 2017

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Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

22 September 2017

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Specific role of Chk1 phosphorylations in cell survival and checkpoint activation

22 September 2017

1 reference

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

22 September 2017

1 reference

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Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

22 September 2017

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

22 September 2017

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

22 September 2017

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

22 September 2017

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Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

22 September 2017

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

22 September 2017

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SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

22 September 2017

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Lack of PTEN sequesters CHK1 and initiates genetic instability.

22 September 2017

1 reference

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Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

22 September 2017

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

22 September 2017

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Chk1 in the DNA damage response: conserved roles from yeasts to mammals

22 September 2017

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Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase

22 September 2017

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

22 September 2017

1 reference

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Chk1 and Chk2 kinases in checkpoint control and cancer

22 September 2017

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Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

22 September 2017

1 reference

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Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

22 September 2017

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A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

22 September 2017

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

22 September 2017

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

22 September 2017

1 reference

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

22 September 2017

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

22 September 2017

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

22 September 2017

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The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

22 September 2017

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Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

22 September 2017

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Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation

22 September 2017

1 reference

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Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation

22 September 2017

1 reference

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Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

25 September 2017

1 reference

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Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes

17 June 2018

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Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

17 June 2018

1 reference

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PD 98059 prevents establishment of the spindle assembly checkpoint and inhibits the G2-M transition in meiotic but not mitotic cell cycles in Xenopus.

20 August 2018

1 reference

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2009.102

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2009.102

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421147%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421147%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference