The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL. (Q39860473)
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scientific article published on 16 April 2009
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL. |
scientific article published on 16 April 2009 |
Statements
The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL (English)
M Schüll
Z Zhao
C Oancea
A Hundertmark
16 April 2009
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