Intracellular antibodies and cancer: new technologies offer therapeutic opportunities (Q39864280)

15 September 2017

Intracellular antibodies and cancer: new technologies offer therapeutic opportunities (English)

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15 September 2017

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Terence H Rabbitts

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author name string

David Pérez-Martínez

series ordinal

1

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PubMed ID

20544739

15 September 2017

Tomoyuki Tanaka

series ordinal

2

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PubMed ID

20544739

15 September 2017

language of work or name

English

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publication date

1 July 2010

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15 September 2017

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15 September 2017

32

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15 September 2017

7

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15 September 2017

589-598

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Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery

15 September 2017

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

21 January 2018

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Antibody engineering and modification technologies

21 January 2018

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Intracellular antibodies and challenges facing their use as therapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201000009

Intrabody applications in neurological disorders: progress and future prospects

21 January 2018

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Stability engineering of antibody single-chain Fv fragments

21 January 2018

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Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies

21 January 2018

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Functional intracellular antibody fragments do not require invariant intra-domain disulfide bonds

21 January 2018

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Interfering with protein-protein interactions: potential for cancer therapy

21 January 2018

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Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting

21 January 2018

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Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR).

21 January 2018

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Intrabody-mediated phenotypic knockout of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes

21 January 2018

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A novel genetic system to detect protein-protein interactions

21 January 2018

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Selection of antibodies for intracellular function using a two-hybrid in vivo system

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201000009

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein

21 January 2018

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The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies

21 January 2018

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Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201000009

Intracellular antibodies for proteomics

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201000009

Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201000009

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

21 January 2018

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An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions

21 January 2018

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The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

21 January 2018

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Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia

21 January 2018

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In vivo selection of intrabodies specifically targeting protein-protein interactions: a general platform for an "undruggable" class of disease targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains

21 January 2018

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A hapten-specific chimaeric IgE antibody with human physiological effector function.

21 January 2018

1 reference

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Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy.

21 January 2018

1 reference

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A protein silencing switch by ligand-induced proteasome-targeting intrabodies

21 January 2018

1 reference

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Synthetic activation of caspases: artificial death switches

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Selection of complementary single-variable domains for building monoclonal antibodies to native proteins

21 January 2018

1 reference

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Themes and variations on ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Recent advances with liposomes as pharmaceutical carriers

21 January 2018

1 reference

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Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers

21 January 2018

1 reference

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Nanocarriers as an emerging platform for cancer therapy

21 January 2018

1 reference

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Delivery of therapeutic proteins

21 January 2018

1 reference

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Recent advances in the use of cell-penetrating peptides for medical and biological applications

21 January 2018

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Gene therapy: twenty-first century medicine

21 January 2018

1 reference

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Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

21 January 2018

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Progress and problems with the use of viral vectors for gene therapy

21 January 2018

1 reference

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DNA-carrier proteins for targeted gene delivery

21 January 2018

1 reference

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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

21 January 2018

1 reference

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Subcellular targeting strategies for drug design and delivery

21 January 2018

1 reference

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Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

21 January 2018

1 reference

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Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers

21 January 2018

1 reference

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beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

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Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

21 January 2018

1 reference

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Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

21 January 2018

1 reference

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Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

21 January 2018

1 reference

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Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments

21 January 2018

1 reference

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An scFv intrabody against the nonamyloid component of alpha-synuclein reduces intracellular aggregation and toxicity

21 January 2018

1 reference

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Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody

21 January 2018

1 reference

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Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intr

21 January 2018

1 reference

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Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines.

21 January 2018

1 reference

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Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity

21 January 2018

1 reference

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Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

21 January 2018

1 reference

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Recombinant human antibodies against the reverse transcriptase of human immunodeficiency virus type-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies

21 January 2018

1 reference

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Intracellular immunization against HIV-1 infection of human T lymphocytes: utility of anti-rev single-chain variable fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Intracellular anti-E7 human antibodies in single-chain format inhibit proliferation of HPV16-positive cervical carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Direct phage to intrabody screening (DPIS): demonstration by isolation of cytosolic intrabodies against the TES1 site of Epstein Barr virus latent membrane protein 1 (LMP1) that block NF-kappaB transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Phenotypic knock-out of the latent membrane protein 1 of Epstein-Barr virus by an intracellular single-chain antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Design and selection of an intrabody library produced de-novo for the non-structural protein NSP5 of rotavirus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Intracellular immunization with cytosolic recombinant antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Characterization of anti-cyclin E single-chain Fv antibodies and intrabodies in breast cancer cells: enhanced intracellular stability of novel sFv-F(c) intrabodies

21 January 2018

1 reference

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Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Anti-VEGFR-2 scFvs for cell isolation. Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/flk-1) on the surface of primary endothelial cells and preselected CD34+ cells from cord blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Human single-domain neutralizing intrabodies directed against Etk kinase: a novel approach to impair cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Cloning of apoB intrabodies: specific knockdown of apoB in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Characterization of a single-chain intrabody directed against the human receptor tyrosine kinase Ron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Cell-penetrating CNTs for delivery of therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

Production of functional chimaeric mouse/human antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201000009

21 January 2018

Identifiers

DOI

10.1002/BIES.201000009

1 reference

15 September 2017

1 reference

PubMed ID

20544739