High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol (Q33235641)

24 July 2017

High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol (English)

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24 July 2017

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Sun Wook Hwang

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Ardem Patapoutian

series ordinal

7

object named as

Ardem Patapoutian

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24 July 2017

1

Michael Bandell

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24 July 2017

2

Adrienne E Dubin

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24 July 2017

5

Jayanti Mathur

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24 July 2017

3

Matt J Petrus

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24 July 2017

Anthony Orth

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PubMed ID

16520735

24 July 2017

language of work or name

English

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publication date

5 March 2006

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24 July 2017

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24 July 2017

9

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24 July 2017

493-500

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24 July 2017

4

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https://scigraph.springernature.com/pub.10.1038/nn1665

24 July 2017

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cites work

A TRP channel that senses cold stimuli and menthol

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7 January 2021

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

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7 January 2021

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

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7 January 2021

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

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7 January 2021

Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.

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7 January 2021

The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

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7 January 2021

Pungent products from garlic activate the sensory ion channel TRPA1

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7 January 2021

The capsaicin receptor: a heat-activated ion channel in the pain pathway

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7 January 2021

Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.

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7 January 2021

Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate.

1 reference

7 January 2021

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain

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7 January 2021

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

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7 January 2021

Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.

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7 January 2021

Molecular basis for species-specific sensitivity to "hot" chili peppers

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7 January 2021

Agonist recognition sites in the cytosolic tails of vanilloid receptor 1.

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7 January 2021

The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel

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7 January 2021

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

1 reference

7 January 2021

High-resolution crystal structure of cytochrome P450cam

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7 January 2021

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

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7 January 2021

Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels

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7 January 2021

Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels

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7 January 2021

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

1 reference

7 January 2021

Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay

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7 January 2021

A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization.

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7 January 2021

Molecular mechanism of cyclic-nucleotide-gated channel activation

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7 January 2021

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

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7 January 2021

Identification of a tetramerization domain in the C terminus of the vanilloid receptor.

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7 January 2021

Quickening the pace: looking into the heart of HCN channels.

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7 January 2021

Cyclic nucleotide-gated ion channels

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7 January 2021

CNG and HCN channels: two peas, one pod.

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7 January 2021

Rotational movement during cyclic nucleotide-gated channel opening

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7 January 2021

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

1 reference

7 January 2021

Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel

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7 January 2021

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

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7 January 2021

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

1 reference

7 January 2021

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

1 reference

7 January 2021

X-ray structure of a voltage-dependent K+ channel

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7 January 2021

Identifiers

DOI

10.1038/NN1665

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24 July 2017

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PubMed ID

16520735