Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. (Q39959127)

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11 January 2020

title

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index (English)

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11 January 2020

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11 January 2020

author name string

Helga Raab

2

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11 January 2020

Suzanna Clark

3

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11 January 2020

Sunil Bhakta

4

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11 January 2020

Douglas D Leipold

5

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11 January 2020

Sylvia Weir

6

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11 January 2020

Yvonne Chen

7

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11 January 2020

Michelle Simpson

8

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11 January 2020

Siao Ping Tsai

9

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11 January 2020

Mark S Dennis

10

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11 January 2020

Yanmei Lu

11

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11 January 2020

Y Gloria Meng

12

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11 January 2020

Carl Ng

13

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11 January 2020

Jihong Yang

14

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11 January 2020

Chien C Lee

15

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11 January 2020

Eileen Duenas

16

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11 January 2020

Jeffrey Gorrell

17

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11 January 2020

Viswanatham Katta

18

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11 January 2020

Amy Kim

19

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11 January 2020

Kevin McDorman

20

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11 January 2020

Kelly Flagella

21

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11 January 2020

Rayna Venook

22

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11 January 2020

Sarajane Ross

23

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11 January 2020

Susan D Spencer

24

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11 January 2020

Wai Lee Wong

25

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11 January 2020

Henry B Lowman

26

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11 January 2020

Richard Vandlen

27

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11 January 2020

Mark X Sliwkowski

28

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11 January 2020

Richard H Scheller

29

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11 January 2020

Paul Polakis

30

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11 January 2020

William Mallet

31

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11 January 2020

publication date

20 July 2008

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11 January 2020

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11 January 2020

volume

26

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11 January 2020

issue

8

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11 January 2020

page(s)

925-932

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https://scigraph.springernature.com/pub.10.1038/nbt.1480

11 January 2020

exact match

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Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

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Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity

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cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

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Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance

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7 January 2021

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7 January 2021

One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge

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Conversion of incomplete antibodies to direct agglutinins by mild reduction: evidence for segmental flexibility within the Fc fragment of immunoglobulin G

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Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond

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Site-specific attachment to recombinant antibodies via introduced surface cysteine residues

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Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies

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Structural effect of a recombinant monoclonal antibody on hinge region peptide bond hydrolysis

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