Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators (Q39966664)

16 September 2017

title

Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators (English)

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(3S,5S,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-methoxy-6-methyloxan-2-yl]oxy-5,12,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde

16 September 2017

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(3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde

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(3S,5S,8R,9S,10S,13R,14S,17R)-3-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-methoxy-6-methyloxan-2-yl]oxy-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde

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(3S,5S,8R,9S,10S,12R,13S,14S,17R)-5,12,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde

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3-O-alpha-L-Rhamnopyranosylcannogenol

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3-[(6-Deoxyhexopyranosyl)oxy]-5,12,14-trihydroxy-19-oxocard-20(22)-enolide

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(3S,5S,10R,13R,14S,17R)-14-hydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,5S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-10-carbaldehyde

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3,5,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carboxaldehyde

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3-[14-hydroxy-10-(hydroxymethyl)-13-methyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

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3,5,14,19-Tetrahydroxycard-20(22)-enolide

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Miao-Miao Jiang

1

1 reference

16 September 2017

Yi Dai

2

1 reference

16 September 2017

Hao Gao

3

1 reference

16 September 2017

Xue Zhang

4

1 reference

16 September 2017

Guang-Hui Wang

5

1 reference

16 September 2017

Jia-You He

6

1 reference

16 September 2017

Qiong-Ying Hu

7

1 reference

16 September 2017

Jin-Zhang Zeng

8

1 reference

16 September 2017

Xiao-Kun Zhang

9

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16 September 2017

Xin-Sheng Yao

10

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16 September 2017

language of work or name

English

1 reference

Chemical & Pharmaceutical Bulletin

publication date

2008

3 references

16 September 2022

16 September 2022

full work available at URL

https://www.jstage.jst.go.jp/article/cpb/56/7/56_7_1005/_pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1248/cpb.56.1005?email=unpaywall_01@example.com

published in

Chemical & Pharmaceutical Bulletin

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16 September 2017

volume

56

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16 September 2017

issue

7

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16 September 2017

page(s)

1005-1008

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https://api.unpaywall.org/v2/10.1248/cpb.56.1005?email=unpaywall_01@example.com

16 September 2017

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19 March 2024

access restriction status

open access

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based on heuristic

inferred from online access status

cites work

Antiproliferative Activity of Cardenolides Isolated from Streptocaulon juventas

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Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting

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The digitalis-like steroid hormones: new mechanisms of action and biological significance

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Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5.

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Targeting Nur77 translocation

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12 April 2024

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p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction

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12 April 2024

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Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis.

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12 April 2024

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

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Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth

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12 April 2024

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Toxicarioside B and toxicarioside C. New cardenolides isolated from Antiaris toxicaria latex-derived dart poison

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12 April 2024

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Die Cardenolide der Samen von Antiaris toxicaria Lesch. 1. Mitteilung: Isolierungen und Identifizierungen Glykoside und Aglykone, 258. Mitteilung

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12 April 2024

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Induction of apoptosis by TPA and VP-16 is through translocation of TR3

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12 April 2024

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Cardiac glycosides from the leaves of Thevetia neriifolia

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Orphan nuclear receptor Nur77 translocates to mitochondria in the early phase of apoptosis induced by synthetic chenodeoxycholic acid derivatives in human stomach cancer cell line SNU-1.

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Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

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12 April 2024

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Toxicarioside A. A new cardenolide isolated from Antiaris toxicaria latex-derived dart poison. Assignment of the 1H- and 13C-NMR shifts for an antiarigenin aglycone

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12 April 2024

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[Cannogenol-3-O-alpha-L-rhamnoside and cannogenol-3-O-beta-D-allomethyloside, two new cardiac glycosides from Convallaria majalis (author's transl)]

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12 April 2024

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Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

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Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition.

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12 April 2024

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Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

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12 April 2024

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Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1248/CPB.56.1005

Identifiers

DOI

10.1248/CPB.56.1005

1 reference

16 September 2017

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