The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity (Q39967020)

16 September 2017

The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity (English)

1 reference

16 September 2017

Paul A Wender

1

1 reference

PMCID

2730840

16 September 2017

Vishal A Verma

series ordinal

2

1 reference

PMCID

2730840

16 September 2017

language of work or name

English

0 references

publication date

28 June 2008

1 reference

16 September 2017

1 reference

16 September 2017

10

1 reference

16 September 2017

3331-3334

1 reference

16 September 2017

15

1 reference

Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Function-oriented synthesis, step economy, and drug design

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Design and synthesis of a potent phorboxazole C(11-15) acetal analogue

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Bryostatin-1: a novel PKC inhibitor in clinical development

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

The protein kinase complement of the human genome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

The practical synthesis of a novel and highly potent analogue of bryostatin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyrans

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Total Synthesis of Bryostatin 3

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Bax:Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Sequential catalytic asymmetric allylic transfer reaction: enantioselective and diastereoselective construction of tetrahydropyran units

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730840

Potent cytotoxins produced by a microbial symbiont protect host larvae from predation

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18588309

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18588309

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18588309

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/OL801235H

1 reference

16 September 2017

1 reference

16 September 2017

1 reference

PMCID

2730840