Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10. (Q39969906)

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English	Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10. (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

author name string

Mark J Dobrzanski

1

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Europe PubMed Central

PubMed publication ID

16 September 2017

Joyce B Reome

2

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Europe PubMed Central

PubMed publication ID

16 September 2017

James C Hylind

3

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Europe PubMed Central

PubMed publication ID

16 September 2017

Kathleen A Rewers-Felkins

4

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Europe PubMed Central

PubMed publication ID

16 September 2017

Khaliquzzaman Abdulsamad

5

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Europe PubMed Central

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16 September 2017

Shawna L Adams

6

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Europe PubMed Central

PubMed publication ID

16 September 2017

publication date

1 January 2008

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Europe PubMed Central

PubMed publication ID

16 September 2017

Immunological Investigations

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Europe PubMed Central

PubMed publication ID

16 September 2017

37

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Europe PubMed Central

PubMed publication ID

16 September 2017

4

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Europe PubMed Central

PubMed publication ID

16 September 2017

315-338

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Europe PubMed Central

PubMed publication ID

16 September 2017

Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells

1 reference

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Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)

1 reference

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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

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Allogeneic lymphocytes induce tumor regression of advanced metastatic breast cancer

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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

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Timeline: Chemotherapy and the war on cancer.

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Resurrecting CD8+ suppressor T cells

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Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles

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Differential antitumor immunity mediated by NKT cell subsets in vivo

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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Tc1 and Tc2 effector cell therapy elicit long-term tumor immunity by contrasting mechanisms that result in complementary endogenous type 1 antitumor responses

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CD8-mediated type 1 antitumor responses selectively modulate endogenous differentiated and nondifferentiated T cell localization, activation, and function in progressive breast cancer

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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

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Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells.

1 reference

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Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets

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NKT cells: what's in a name?

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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The pharmacology and clinical use of methotrexate

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Distinct NKT cell subsets are induced by different Chlamydia species leading to differential adaptive immunity and host resistance to the infections

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Signal transduction from the extracellular matrix

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Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells

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Tumors as elusive targets of T-cell-based active immunotherapy

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Sensitization of cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity.

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Drug penetration in solid tumours

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Immune suppression and skin cancer development: regulation by NKT cells.

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Interleukin-10 and the interleukin-10 receptor

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TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma

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DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells

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Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

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Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.

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Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

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Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo

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Integrins: emerging paradigms of signal transduction

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Molecular identification of a danger signal that alerts the immune system to dying cells

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Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells

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New aspects of natural-killer-cell surveillance and therapy of cancer

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CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer

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Regulation of mature T cell homeostasis

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IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

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Identifiers

10.1080/08820130802083762

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

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