A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor (Q39972614)

16 September 2017

title

A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor (English)

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16 September 2017

Chris J van Koppen

1

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16 September 2017

Guido J R Zaman

2

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16 September 2017

C Marco Timmers

3

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16 September 2017

Jan Kelder

4

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16 September 2017

Sietse Mosselman

5

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16 September 2017

Ruud van de Lagemaat

6

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16 September 2017

Martin J Smit

7

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16 September 2017

Rob G J M Hanssen

8

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16 September 2017

publication date

13 June 2008

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Naunyn-Schmiedeberg's Archives of Pharmacology

16 September 2017

published in

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16 September 2017

volume

378

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16 September 2017

issue

5

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16 September 2017

page(s)

503-514

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https://scigraph.springernature.com/pub.10.1007/s00210-008-0318-3

16 September 2017

exact match

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cites work

Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00210-008-0318-3

A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

21 January 2018

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12 December 2020

Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region

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Characterization of two fly LGR (leucine-rich repeat-containing, G protein-coupled receptor) proteins homologous to vertebrate glycoprotein hormone receptors: constitutive activation of wild-type fly LGR1 but not LGR2 in transfected mammalian cells

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12 December 2020

Luteinizing hormone increases inositol trisphosphate and cytosolic free Ca2+ in isolated bovine luteal cells

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12 December 2020

Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies

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12 December 2020

Identification and characterization of a selective, nonpeptide follicle-stimulating hormone receptor antagonist

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12 December 2020

The first orally active low molecular weight agonists for the LH receptor: thienopyr(im)idines with therapeutic potential for ovulation induction

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12 December 2020

Roles of transmembrane prolines and proline-induced kinks of the lutropin/choriogonadotropin receptor

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12 December 2020

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

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12 December 2020

Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor

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12 December 2020

5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists

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12 December 2020

Allosteric activation of the follicle-stimulating hormone (FSH) receptor by selective, nonpeptide agonists.

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12 December 2020

Preparation of highly substituted gamma-lactam follicle stimulating hormone receptor agonists.

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12 December 2020

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

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12 December 2020

Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists

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12 December 2020

Common and differential mechanisms of gonadotropin receptors

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12 December 2020

Cloning, sequencing and expression of human TSH receptor

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12 December 2020

Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species

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12 December 2020

The C-terminal third of the human luteinizing hormone (LH) receptor is important for inositol phosphate release: analysis using chimeric human LH/follicle-stimulating hormone receptors

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12 December 2020

Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists

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12 December 2020

The origins of diversity and specificity in g protein-coupled receptor signaling

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12 December 2020

The luteinizing hormone/chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals

1 reference

12 December 2020

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

1 reference

12 December 2020

A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone

1 reference

12 December 2020

[3H]Org 43553, the first low-molecular-weight agonistic and allosteric radioligand for the human luteinizing hormone receptor

1 reference

12 December 2020

Efficacy at G-protein-coupled receptors

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12 December 2020

Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat

1 reference

12 December 2020

Multiple signaling states of G-protein-coupled receptors

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12 December 2020

10.1007/S00210-008-0318-3

Identifiers

DOI

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16 September 2017

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