Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. (Q39974501)

16 September 2017

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. (English)

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16 September 2017

Melanie Winter

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16 September 2017

Dirk Sombroek

2

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16 September 2017

Ilka Dauth

3

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16 September 2017

Jutta Moehlenbrink

4

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16 September 2017

Karin Scheuermann

5

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16 September 2017

Johanna Crone

6

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16 September 2017

Thomas G Hofmann

7

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16 September 2017

8 June 2008

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16 September 2017

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16 September 2017

7

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16 September 2017

812-824

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https://scigraph.springernature.com/pub.10.1038/ncb1743

16 September 2017

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The many substrates and functions of ATM

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

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The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

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High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

21 January 2018

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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

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Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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Body language: the function of PML nuclear bodies in apoptosis regulation

21 January 2018

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Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

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Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

21 January 2018

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C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs

21 January 2018

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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

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Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

21 January 2018

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Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

21 January 2018

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SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis

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SIAH-1 inhibits cell growth by altering the mitotic process

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The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome

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p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

21 January 2018

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Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

21 January 2018

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Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

21 January 2018

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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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A binding motif for Siah ubiquitin ligase.

21 January 2018

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Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.

21 January 2018

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Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

21 January 2018

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p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

21 January 2018

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p53 ubiquitination: Mdm2 and beyond

21 January 2018

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Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter

21 January 2018

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Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner.

21 January 2018

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Decision making by p53: life, death and cancer

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

21 January 2018

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

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Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.

21 January 2018

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Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.

21 January 2018

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FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies

21 January 2018

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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Degrading liaisons: Siah structure revealed

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

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inferred from DOI database lookup

7 January 2021

based on heuristic

Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCB1743

1 reference

16 September 2017

1 reference