Decision making by p53: life, death and cancer (Q35116663)

6 August 2017

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title

Decision making by p53: life, death and cancer (English)

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6 August 2017

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Oren M

1

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6 August 2017

1 April 2003

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Cell Death & Differentiation

6 August 2017

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6 August 2017

10

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6 August 2017

431-442

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6 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401183

6 August 2017

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cites work

Introduction: p53--the first twenty years

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53-Mdm2--the affair that never ends

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Stress signals utilize multiple pathways to stabilize p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Multiple roles of the tumor suppressor p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The role of p53 and pRB in apoptosis and cancer

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The p53 and Mdm2 families in cancer.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Signaling networks that link cell proliferation and cell fate

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53-dependent apoptosis pathways.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Surfing the p53 network

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Regulation of p53 function

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

MDM2: life without p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Function and dysfunction of the human oncoprotein MDM2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

NQO1 stabilizes p53 through a distinct pathway

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

JNK targets p53 ubiquitination and degradation in nonstressed cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

JunD protects cells from p53-dependent senescence and apoptosis.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Role of NF-κB in p53-mediated programmed cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

ASPP proteins specifically stimulate the apoptotic function of p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A novel cofactor for p300 that regulates the p53 response

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Kinetics of p53 binding to promoter sites in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A polymorphic microsatellite that mediates induction of PIG3 by p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

hADA3 is required for p53 activity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Wild-type p53 can down-modulate the activity of various promoters

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53, caspase 8, and regulation of apoptosis after ionizing radiation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Nuclear and mitochondrial apoptotic pathways of p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Anti-apoptotic activity of p53 maps to the COOH-terminal domain and is retained in a highly oncogenic natural mutant

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Genetic determinants of p53-induced apoptosis and growth arrest

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Excess beta-catenin promotes accumulation of transcriptionally active p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Activation of p53 by oncogenes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

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7 January 2021

ARF differentially modulates apoptosis induced by E2F1 and Myc.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Down-regulation of beta-catenin by activated p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

On the shoulders of giants: p63, p73 and the rise of p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

DeltaNp63 induces beta-catenin nuclear accumulation and signaling

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

The protein kinase B/Akt signalling pathway in human malignancy

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Phosphorylation of HDM2 by Akt.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Regulation of PTEN transcription by p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Signal transduction: signaling specificity- a complex affair

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Akt participation in the Wnt signaling pathway through Dishevelled

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Dissecting p53 tumor suppressor functions in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401183

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401183

1 reference

6 August 2017

1 reference

PubMed ID

12719720