Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. (Q40013835)

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2 January 2020

title

Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif (English)

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2 January 2020

6

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7

Bart Vanhaesebroeck

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2 January 2020

author name string

Yen-Chung Chen

1

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2 January 2020

Hsiu-Yin Chiang

2

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2 January 2020

Muh-Hwa Yang

3

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2 January 2020

Po-Min Chen

4

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2 January 2020

Shyue-Yih Chang

5

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2 January 2020

Kou-Juey Wu

8

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2 January 2020

publication date

13 February 2008

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Journal of Molecular Medicine

2 January 2020

published in

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volume

86

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issue

4

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2 January 2020

page(s)

401-412

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https://scigraph.springernature.com/pub.10.1007/s00109-008-0302-x

2 January 2020

exact match

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cites work

Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt

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12 December 2020

Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks

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12 December 2020

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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12 December 2020

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

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12 December 2020

Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development

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12 December 2020

Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

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12 December 2020

Akt activation by growth factors is a multiple-step process: the role of the PH domain

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repair

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12 December 2020

Signalling through Class I PI3Ks in mammalian cells

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12 December 2020

AKT plays a central role in tumorigenesis

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12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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12 December 2020

Signaling by distinct classes of phosphoinositide 3-kinases

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12 December 2020

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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12 December 2020

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

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12 December 2020

NBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiation

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12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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12 December 2020

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

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12 December 2020

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

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12 December 2020

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

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12 December 2020

A murine model of Nijmegen breakage syndrome

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12 December 2020

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

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12 December 2020

Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?

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12 December 2020

Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation

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12 December 2020

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

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12 December 2020

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

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12 December 2020

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

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12 December 2020

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

1 reference

12 December 2020

The phosphoinositide 3-kinase pathway

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12 December 2020

Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer

1 reference

12 December 2020

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

1 reference

12 December 2020

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

1 reference

12 December 2020

10.1007/S00109-008-0302-X

Identifiers

DOI

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release_jwpbdarcrzbipa4jjteykvepmu

2 January 2020

Fatcat ID

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