Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. (Q40024347)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

0 references

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

W Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

M Konopleva

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

V R Ruvolo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

T McQueen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

R L Evans

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

W G Bornmann

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

J Cortes

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

M Andreeff

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

language of work or name

1 reference

17 January 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

808-818

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.leu.2405098

1 January 2020

exact match

0 references

cites work

Targeting RAS signalling pathways in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Ways of dying: multiple pathways to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Design and discovery of small molecules targeting raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Antitumor activity of sorafenib in FLT3-driven leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Cytokine-regulated expression of survivin in myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

Results of a phase I trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

7 January 2021

Cell-surface exposure of phosphatidylserine correlates with the stage of fludarabine-induced apoptosis in chronic lymphocytic leukemia and expression of apoptosis-regulating genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

7 January 2021

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

7 January 2021

Haematopoietic response and bcl-2 expression in patients with acute myeloid leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2405098

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2405098

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18200035%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 January 2020

0 references

1 reference