Influence of positive allosteric modulators on GABA(B) receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes (Q40049789)

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scientific article published on 16 November 2007

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English	Influence of positive allosteric modulators on GABA(B) receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes	scientific article published on 16 November 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

16 September 2017

Influence of positive allosteric modulators on GABA(B) receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes (English)

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Europe PubMed Central

PubMed publication ID

16 September 2017

author name string

Clotilde Mannoury la Cour

1

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Europe PubMed Central

PubMed publication ID

16 September 2017

Chloé Herbelles

2

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Europe PubMed Central

PubMed publication ID

16 September 2017

Valérie Pasteau

3

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Europe PubMed Central

PubMed publication ID

16 September 2017

Guillaume de Nanteuil

4

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16 September 2017

Mark J Millan

5

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16 September 2017

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publication date

16 November 2007

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Europe PubMed Central

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16 September 2017

Journal of Neurochemistry

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16 September 2017

105

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Europe PubMed Central

PubMed publication ID

16 September 2017

2

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Europe PubMed Central

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16 September 2017

308-323

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Europe PubMed Central

PubMed publication ID

16 September 2017

gamma-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distribution

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Molecular structure and physiological functions of GABA(B) receptors

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GABA(B) receptor isoforms GBR1a and GBR1b, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum

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The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

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Antagonism of baclofen-induced depression of whole-cell synaptic currents in spinal dorsal horn neurones by the potent GABAB antagonist CGP55845.

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GABAB receptors and their significance in mammalian pharmacology

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(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.

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International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function

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Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain

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Pre- and postsynaptic GABAB receptors of rat neocortical neurons differ in their pharmacological properties

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Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties

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SGS742: the first GABA(B) receptor antagonist in clinical trials

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Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

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GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy

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gamma-Aminobutyric acidB receptors in the rat brain: quantitative autoradiographic localization using [3H](-)-baclofen.

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Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain

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Activation of muscarinic acetylcholine receptors via their allosteric binding sites.

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The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

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Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

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GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

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Baclofen prevents morphine withdrawal irrespective of seasonal variation

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Regional effects of pertussis toxin in vivo and in vitro on GABAB receptor binding in rat brain

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Gabapentin is not a GABAB receptor agonist

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The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel

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Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain

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Dopamine D1 receptor coupling to Gs/olf and Gq in rat striatum and cortex: a scintillation proximity assay (SPA)/antibody-capture characterization of benzazepine agonists

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Immunohistochemical localization of GABA(B) receptors in the rat central nervous system

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A trafficking checkpoint controls GABA(B) receptor heterodimerization

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Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

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CGP 36,742, an orally active GABAB receptor antagonist, facilitates memory in a social recognition test in rats.

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Somatostatin receptor-mediated signaling in smooth muscle. Activation of phospholipase C-beta3 by Gbetagamma and inhibition of adenylyl cyclase by Galphai1 and Galphao

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Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

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Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties.

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Differential compartmentalization and distinct functions of GABAB receptor variants

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21 January 2018

Identifiers

10.1111/J.1471-4159.2007.05131.X

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

ResearchGate publication ID

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