Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. (Q40068834)

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8 January 2020

title

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases (English)

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8 January 2020

4

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author name string

Adam Shutes

1

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8 January 2020

Cercina Onesto

2

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8 January 2020

Virginie Picard

3

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8 January 2020

Fabien Schweighoffer

5

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8 January 2020

Channing J Der

6

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language of work or name

English

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publication date

11 October 2007

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Journal of Biological Chemistry

8 January 2020

published in

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8 January 2020

volume

282

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issue

49

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8 January 2020

page(s)

35666-35678

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Rho-family GTPases: it's not only Rac and Rho (and I like it).

8 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rho GTPases: biochemistry and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Ras and Rho GTPases: a family reunion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

The role of Rho GTPases in disease development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

21 January 2018

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

21 January 2018

Rho proteins and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rac is required for v-Abl tyrosine kinase to activate mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Mas oncogene signaling and transformation require the small GTP-binding protein Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

A role for Rac in Tiam1-induced membrane ruffling and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Expression of Rac3 in human brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

VAV1: a new target in pancreatic cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Lipid posttranslational modifications. Farnesyl transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

RhoG signals in parallel with Rac1 and Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

The mechanism of Ras GTPase activation by neurofibromin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Role of magnesium in nucleotide exchange on the small G protein rac investigated using novel fluorescent Guanine nucleotide analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Ras-Cdc25 and Rho-Dbl binding assays: complex formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

The Ras superfamily at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

GAP control: regulating the regulators of small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703571200

21 January 2018

Identifiers

DOI

10.1074/JBC.M703571200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932039%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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