The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. (Q40074115)

17 September 2017

title

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. (English)

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17 September 2017

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17 September 2017

Robert J Harvey

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Nicholas W. Wood

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Nicholas W Wood

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author name string

Hélène Plun-Favreau

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17 September 2017

Kristina Klupsch

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Nicoleta Moisoi

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Sonia Gandhi

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David Frith

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Kirsten Harvey

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Emma Deas

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Neil McDonald

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L Miguel Martins

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language of work or name

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30 September 2007

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17 September 2017

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volume

9

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issue

11

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page(s)

1243-1252

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Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

17 September 2017

cites work

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7 January 2021

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

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7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

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7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

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7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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7 January 2021

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

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7 January 2021

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

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7 January 2021

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

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7 January 2021

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

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7 January 2021

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

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7 January 2021

OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain

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7 January 2021

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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7 January 2021

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

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7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes

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7 January 2021

Novel PINK1 mutations in early-onset parkinsonism

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7 January 2021

Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism

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7 January 2021

Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease

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7 January 2021

Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism

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7 January 2021

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

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7 January 2021

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

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7 January 2021

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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7 January 2021

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

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7 January 2021

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

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7 January 2021

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

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7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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7 January 2021

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

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7 January 2021

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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7 January 2021

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

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7 January 2021

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

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7 January 2021

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

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7 January 2021

MAPKs: new targets for neurodegeneration

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7 January 2021

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

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7 January 2021

A stress sensor for the bacterial periplasm

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7 January 2021

A heterozygous effect for PINK1 mutations in Parkinson's disease?

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7 January 2021

PINK1 protein in normal human brain and Parkinson's disease

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7 January 2021

Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells.

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7 January 2021

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

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7 January 2021

Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint

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7 January 2021

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

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7 January 2021

High content screening applied to large-scale cell biology

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7 January 2021

Identifiers

DOI

10.1038/NCB1644

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17 September 2017

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