c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy. (Q40076507)

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8 January 2020

title

c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy (English)

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8 January 2020

1

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8 January 2020

Javier Hernandez-Losa

2

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Miguel A De la Cruz-Morcillo

8 January 2020

4

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8 January 2020

Santiago Ramon y Cajal

9

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8 January 2020

Ricardo Sanchez-Prieto

11

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8 January 2020

author name string

Clara I Aceves Luquero

3

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8 January 2020

Carmen Ramírez-Castillejo

5

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8 January 2020

Juan L Callejas-Valera

6

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8 January 2020

Angel Arriaga

7

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8 January 2020

Antonio Fernandez Aranburo

8

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8 January 2020

J Silvio Gutkind

10

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8 January 2020

language of work or name

English

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publication date

1 January 2008

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International Journal of Cancer

8 January 2020

published in

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volume

122

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issue

2

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8 January 2020

page(s)

289-297

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

8 January 2020

cites work

1 reference

The biology of p38 kinase: a central role in inflammation

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p38 MAP kinase's emerging role as a tumor suppressor

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p38 MAP kinase: a convergence point in cancer therapy

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Mechanism of p38 MAP kinase activation in vivo.

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

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c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-beta-D-arabinofuranosylcytosine

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Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

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Cisplatin: mode of cytotoxic action and molecular basis of resistance

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

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Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl.

21 January 2018

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Role of the p38 MAPK pathway in cisplatin-based therapy

21 January 2018

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The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin

21 January 2018

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Cisplatin induces a persistent activation of JNK that is related to cell death

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c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation

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Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage

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Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

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c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination

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Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571.

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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STI571 (Gleevec) as a paradigm for cancer therapy

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Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway

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Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

21 January 2018

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Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance

21 January 2018

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Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells

21 January 2018

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Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival

21 January 2018

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Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma

21 January 2018

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Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

21 January 2018

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A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins

21 January 2018

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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

21 January 2018

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Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

21 January 2018

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