Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. (Q40084486)

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5 January 2020

title

Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway (English)

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5 January 2020

1

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5 January 2020

Tzuu-Shuh Jou

5

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6

Michael A Matthay

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5 January 2020

author name string

Anirban Datta

2

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5 January 2020

Wei Yu

3

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5 January 2020

Paul R Brakeman

4

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5 January 2020

Keith E Mostov

7

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publication date

5 September 2007

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American Journal of Physiology - Renal Physiology

5 January 2020

published in

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volume

293

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issue

5

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page(s)

F1633-40

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Rho and Rac take center stage

5 January 2020

cites work

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Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.

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Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells

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Origins of cell polarity

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

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Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1

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Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells

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Cell polarity: the ups and downs of the Par6/aPKC complex

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Organogenesis: molecular mechanisms of tubulogenesis

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

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Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity

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A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

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PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

21 January 2018

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The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

21 January 2018

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The Akt pathway: molecular targets for anti-cancer drug development

21 January 2018

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Membrane traffic in polarized epithelial cells

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PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.

21 January 2018

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Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

21 January 2018

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Opinion: Building epithelial architecture: insights from three-dimensional culture models

21 January 2018

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Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.

21 January 2018

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The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.

21 January 2018

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The tight junction: a multifunctional complex

21 January 2018

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APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity

21 January 2018

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Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

21 January 2018

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A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle

21 January 2018

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Cell surface polarity in epithelia.

21 January 2018

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Beta1-integrin orients epithelial polarity via Rac1 and laminin

21 January 2018

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Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures

21 January 2018

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21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17804488%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference