Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. (Q40088642)

17 September 2017

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. (English)

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17 September 2017

3

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17 September 2017

J Averous

1

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17 September 2017

B D Fonseca

series ordinal

2

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17 September 2017

language of work or name

English

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publication date

27 August 2007

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17 September 2017

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17 September 2017

27

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8

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17 September 2017

1106-1113

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210715

17 September 2017

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cites work

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When translation meets transformation: the mTOR story

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Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

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eIF-4E expression and its role in malignancies and metastases.

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A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E

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mTOR and cancer therapy

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AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

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Regulation of translation initiation by FRAP/mTOR

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Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.

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Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

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Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

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Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells

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Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation

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The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

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mTOR, translation initiation and cancer

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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

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The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

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Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

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Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

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mTOR and cancer: insights into a complex relationship

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

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Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

21 January 2018

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Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 January 2018

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TOR signaling in growth and metabolism

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Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1210715

1 reference

Dimensions Publication ID

17 September 2017

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1 reference