mTOR, translation initiation and cancer (Q36623679)

15 August 2017

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title

mTOR, translation initiation and cancer (English)

1 reference

15 August 2017

Mamane Y

1

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15 August 2017

Petroulakis E

series ordinal

2

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15 August 2017

LeBacquer O

series ordinal

3

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15 August 2017

Sonenberg N

series ordinal

4

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

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15 August 2017

25

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15 August 2017

48

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15 August 2017

6416-6422

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209888

15 August 2017

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cites work

Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The TOR signalling network from yeast to man.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational control of the proteome: relevance to cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cellsin vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Upstream and downstream of mTOR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Exploiting the PI3K/AKT pathway for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

A new translational regulator with homology to eukaryotic translation initiation factor 4G

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Tor signalling in bugs, brain and brawn

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Protein synthesis initiation factor 4G.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

eIF4E--from translation to transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Synthesis of the translational apparatus is regulated at the translational level

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Vascular endothelial growth factor expression in early stage ovarian carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational regulation of TRAIL sensitivity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

eIF3: a connecTOR of S6K1 to the translation preinitiation complex.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

mTOR signaling: implications for cancer and anticancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational control of the antiapoptotic function of Ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Role of mTOR Signalling in the Control of Translation Initiation and Elongation by Nutrients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The eukaryotic initiation factor 4E-binding proteins and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Targeting the molecular target of rapamycin (mTOR).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The role of c-myc in regulation of translation initiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Phosphoinositide 3-kinases as drug targets in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Vascular endothelial growth factor-regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

TRAIL and apoptosis induction by TNF-family death receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

mTOR--beyond transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209888

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209888

1 reference

15 August 2017

1 reference