Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus. (Q40102515)

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2 January 2020

title

Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus (English)

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2 January 2020

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2

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John G Hay

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2 January 2020

author name string

Jin Cheng

1

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2 January 2020

YaoQi Huang

3

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2 January 2020

David I Kutler

4

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Sofia Bajwa

5

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William N Rom

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publication date

24 July 2007

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2 January 2020

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2 January 2020

volume

15

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issue

11

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2 January 2020

page(s)

1982-1990

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Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers

2 January 2020

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The end of the beginning: oncolytic virotherapy achieves clinical proof-of-concept

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Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points

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Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effect

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Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

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Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase

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Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling

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Oncolytic virotherapy: approaches to tumor targeting and enhancing antitumor effects

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Pharmacokinetics of oncolytic measles virotherapy: eventual equilibrium between virus and tumor in an ovarian cancer xenograft model

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Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression

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Effect of hypoxia on Ad5 infection, transgene expression and replication.

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Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy

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Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen

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Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis.

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Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion

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Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity

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Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy

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Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.

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7 January 2021

Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.

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7 January 2021

Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model

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7 January 2021

Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression

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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

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Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector

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