Statins reduce amyloid-beta production through inhibition of protein isoprenylation (Q40103529)

17 September 2017

Statins reduce amyloid-beta production through inhibition of protein isoprenylation (English)

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17 September 2017

Stephen M Ostrowski

1

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17 September 2017

Brandy L Wilkinson

series ordinal

2

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17 September 2017

Todd E Golde

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3

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17 September 2017

Gary Landreth

series ordinal

4

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17 September 2017

language of work or name

English

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publication date

23 July 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

37

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17 September 2017

26832-26844

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Statins and the risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

The risk of dementia in relation to statins and other lipid lowering agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Cholesterol in Alzheimer's disease and tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Statin therapy for Alzheimer's disease: will it work?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Is hypercholesterolemia a risk factor for Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Pleiotropic effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Non-lipid-related effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Mechanisms of statin-mediated inhibition of small G-protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Monitoring the cellular effects of HMG-CoA reductase inhibitors in vitro and ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Regulation of the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Clostridium difficile toxins: mechanism of action and role in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Potentially amyloidogenic fragment of 50 kDa and intracellular processing of amyloid precursor protein in cells cultured under leupeptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Isoprenylation is required for the processing of the lamin A precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702640200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702640200

1 reference

17 September 2017

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