Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24. (Q40123401)

17 September 2017

Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24. (English)

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17 September 2017

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Ichiro Tahara

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17 September 2017

Koichi Miyake

2

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17 September 2017

Hideki Hanawa

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17 September 2017

Toshiyuki Kurai

4

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17 September 2017

Yukihiko Hirai

5

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17 September 2017

Masamichi Ishizaki

6

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17 September 2017

Eiji Uchida

7

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17 September 2017

Takashi Tajiri

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17 September 2017

Takashi Shimada

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17 September 2017

5 June 2007

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17 September 2017

1805-1811

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Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas

17 September 2017

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Loss of MDA-7 expression with progression of melanoma

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

mda-7/IL-24: exploiting cancer's Achilles' heel

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Phase I study of recombinant human endostatin in patients with advanced solid tumors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Adeno-associated viral vector-mediated expression of endostatin inhibits tumor growth and metastasis in an orthotropic pancreatic cancer model in hamsters.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Adeno-associated virus 2-mediated intratumoral prostate cancer gene therapy: long-term maspin expression efficiently suppresses tumor growth

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Adeno-associated virus serotypes: vector toolkit for human gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Is mda-7/IL-24 a "magic bullet" for cancer?

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Inadvertent germline transmission of AAV2 vector: findings in a rabbit model correlate with those in a human clinical trial

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Melanoma differentiation-associated gene-7 (mda-7)/interleukin (IL)-24 induces anticancer immunity in a syngeneic murine model

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated -7 (mda-7)/interleukin-24 (IL-24) gene

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Antitumor effect of a new selective matrix metalloproteinase inhibitor, MMI-166, on experimental pancreatic cancer

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300225

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300225

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17 September 2017

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