A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. (Q40549569)

21 September 2017

A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. (English)

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21 September 2017

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4

Paul Dent

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21 September 2017

Yun Dai

1

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21 September 2017

Mohamed Rahmani

series ordinal

2

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21 September 2017

Seth J Corey

series ordinal

3

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21 September 2017

Steven Grant

series ordinal

5

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21 September 2017

language of work or name

English

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publication date

2 June 2004

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Journal of Biological Chemistry

21 September 2017

13

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based on heuristic

inferred from page(s)

published in

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21 September 2017

279

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21 September 2017

33

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21 September 2017

34227-34239

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Alternatively spliced murine lyn mRNAs encode distinct proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Lyn regulates the cell death response to ultraviolet radiation through c-Jun N terminal kinase-dependent Fas ligand activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402290200

21 January 2018

Identifiers

DOI

10.1074/JBC.M402290200

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21 September 2017

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