Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells. (Q40152520)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17394086%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells (English)

1 reference

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28 December 2019

1 reference

1 reference

1

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28 December 2019

Liam Morgan

3

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28 December 2019

author name string

Nicola J Jordan

2

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28 December 2019

Tim P Green

4

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28 December 2019

Robert I Nicholson

5

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28 December 2019

publication date

30 March 2007

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Clinical & Experimental Metastasis

28 December 2019

published in

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28 December 2019

volume

24

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28 December 2019

issue

3

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28 December 2019

page(s)

157-167

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https://scigraph.springernature.com/pub.10.1007/s10585-007-9065-y

28 December 2019

exact match

0 references

cites work

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

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Control of motile and invasive cell phenotypes by focal adhesion kinase.

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Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

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Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

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Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

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Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

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Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

21 January 2018

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12 December 2020

Integrin α3β1-Dependent Activation of FAK/Src Regulates Rac1-Mediated Keratinocyte Polarization on Laminin-5

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Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

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Src in cancer: deregulation and consequences for cell behaviour

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Overexpression of c-Src enhances cell-matrix adhesion and cell migration in PDGF-stimulated NIH3T3 fibroblasts

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Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells

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Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells

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Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis

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Src family kinases in tumor progression and metastasis

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Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors

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pp60c-src activation in lung adenocarcinoma

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Decreased Src tyrosine kinase activity inhibits malignant human ovarian cancer tumor growth in a nude mouse model.

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12 December 2020

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

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FAK regulates biological processes important for the pathogenesis of cancer

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12 December 2020

Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215.

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12 December 2020

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

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12 December 2020

Expression of focal adhesion kinase in normal and pathologic human prostate tissues

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12 December 2020

Ligand binding to integrins

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12 December 2020

Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer

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12 December 2020

Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells

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12 December 2020

Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK.

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12 December 2020

Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells

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12 December 2020

Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia.

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12 December 2020

Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells.

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12 December 2020

Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.

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12 December 2020

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

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12 December 2020

Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

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12 December 2020

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

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12 December 2020

Integrin signalling during tumour progression

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12 December 2020

The interplay between Src and integrins in normal and tumor biology

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12 December 2020

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

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12 December 2020