Src in cancer: deregulation and consequences for cell behaviour (Q33959239)

30 July 2017

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title

Src in cancer: deregulation and consequences for cell behaviour (English)

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30 July 2017

1

Margaret C Frame

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30 July 2017

language of work or name

English

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publication date

1 June 2002

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1602

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30 July 2017

issue

2

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30 July 2017

page(s)

114-130

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30 July 2017

cites work

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7 January 2021

Cellular functions regulated by Src family kinases

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7 January 2021

Expression of a molecularly cloned human c-src oncogene by using a replication-competent retroviral vector

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7 January 2021

Activation of the transforming potential of p60c-src by a single amino acid change

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7 January 2021

pp60c-src activation in human colon carcinoma

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7 January 2021

Activation of pp60c-src protein kinase activity in human colon carcinoma

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7 January 2021

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis

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7 January 2021

Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis

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7 January 2021

Site-specific differences in pp60c-src activity in human colorectal metastases

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7 January 2021

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

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7 January 2021

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

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7 January 2021

Differential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines

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7 January 2021

Activating SRC mutation in a subset of advanced human colon cancers

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7 January 2021

No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients

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7 January 2021

Activation of the Src family of tyrosine kinases in mammary tumorigenesis.

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

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7 January 2021

Src activation in malignant and premalignant epithelia of Barrett's esophagus

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7 January 2021

Expression of pp60c-src in human small cell and non-small cell lung carcinomas

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7 January 2021

Overexpression of c-Src in areas of hyperproliferation in head and neck cancer, premalignant lesions and benign mucosal disorders

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7 January 2021

Aberrant Elevation of Tyrosine-specific Phosphorylation in Human Gastric Cancer Cells

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7 January 2021

c-Src, receptor tyrosine kinases, and human cancer

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Structures of Src-family tyrosine kinases

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Insights into Src kinase functions: structural comparisons

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7 January 2021

A crystal milestone: the structure of regulated Src.

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7 January 2021

Signal transduction: clamping down on Src activity

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7 January 2021

Active and inactive protein kinases: structural basis for regulation

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7 January 2021

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation

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7 January 2021

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions

1 reference

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7 January 2021

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

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7 January 2021

Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis

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7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

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7 January 2021

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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7 January 2021

Src autoinhibition: let us count the ways

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Tyr527 is phosphorylated in pp60c-src: implications for regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

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7 January 2021

Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Constitutive activation of Src family kinases in mouse embryos that lack Csk.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Overexpression of the csk gene suppresses tumor metastasis in vivo

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A phosphotyrosine displacement mechanism for activation of Src by PTPalpha

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Association between the PDGF receptor and members of the src family of tyrosine kinases

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

SH2- and SH3-mediated interactions between focal adhesion kinase and Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Regulation of c-SRC activity and function by the adapter protein CAS

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Association of p60c-src with endosomal membranes in mammalian fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Activation and translocation of c-Src to the cytoskeleton by both platelet-derived growth factor and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

1 reference

7 January 2021

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Ubiquitin-mediated degradation of active Src tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Ubiquitin-dependent degradation of active Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Modulation of the Catalytic Activity of the Src Family Tyrosine Kinase Hck by Autophosphorylation at a Novel Site in the Unique Domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Signaling through focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Regulation of both apoptosis and cell survival by the v-Src oncoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The selective isolation of temperature-sensitive mutants of Rous sarcoma virus

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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Disruption of epithelial cell-matrix interactions induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src family tyrosine kinases and growth factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Multiple roles for Src in a PDGF-stimulated cell

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Altered phosphorylation and activation of pp60c-src during fibroblast mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src family kinases are required for integrin but not PDGFR signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

No requirement for src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Caveolin, a protein component of caveolae membrane coats

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Epidermal Growth Factor-stimulated Tyrosine Phosphorylation of Caveolin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Reduction of caveolin and caveolae in oncogenically transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

RNA Genetics of Breast Cancer: Maspin as Paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A target for Src in mitosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

v-Src induces tyrosine phosphorylation of focal adhesion kinase independently of tyrosine 397 and formation of a complex with Src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Identification and characterization of a novel cytoskeleton-associated pp60src substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Impairment of mobility in endodermal cells by FAK deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Expression of focal adhesion kinase gene and invasive cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Regulation of cell motility by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Rho GTPases control polarity, protrusion, and adhesion during cell movement

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Comparative study of hepatocyte growth factor/scatter factor and keratinocyte growth factor effects on human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Inhibition of RhoA by p120 catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

p120 catenin regulates the actin cytoskeleton via Rho family GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The crossroads between cell-cell adhesion and motility

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Identification of Src phosphorylation sites in the catenin p120ctn

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

p120-catenin expression in human colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A causal role for E-cadherin in the transition from adenoma to carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

E-cadherin germline mutations in familial gastric cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src and Ras are involved in separate pathways in epithelial cell scattering

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Role of c-Src tyrosine kinase in EGF-induced mitogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The transforming activity of activated G alpha 12.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Two G protein oncogenes in human endocrine tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Regulation by Gi2 proteins of v-fms-induced proliferation and transformation via Src-kinase and STAT3.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Src tyrosine kinase is a novel direct effector of G proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Activation and association of Stat3 with Src in v-Src-transformed cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

The mechanism of cell cycle regulation by v-Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900040-9

7 January 2021

10.1016/S0304-419X(02)00040-9

Identifiers

DOI

1 reference

30 July 2017

1 reference