Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. (Q40162927)

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English	Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.	scientific article

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26 December 2019

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer (English)

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26 December 2019

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26 December 2019

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S A Hinke

1

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26 December 2019

Y Cai

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26 December 2019

J Finsi

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26 December 2019

H Heimberg

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26 December 2019

D Pipeleers

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26 December 2019

M Van de Casteele

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26 December 2019

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5 March 2007

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26 December 2019

British Journal of Pharmacology

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26 December 2019

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26 December 2019

1031-1043

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26 December 2019

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26 December 2019

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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22 September 2017

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22 September 2017

AMPK, the metabolic syndrome and cancer

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22 September 2017

Oral Antidiabetic Agents

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22 September 2017

Biochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADH.

1 reference

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22 September 2017

AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms

1 reference

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22 September 2017

Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase

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22 September 2017

Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal

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22 September 2017

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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22 September 2017

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

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22 September 2017

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

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22 September 2017

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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22 September 2017

Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues

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22 September 2017

Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

1 reference

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22 September 2017

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

1 reference

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22 September 2017

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

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22 September 2017

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

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22 September 2017

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

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22 September 2017

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

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22 September 2017

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22 September 2017

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

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22 September 2017

Role of AMP-activated protein kinase in mechanism of metformin action

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22 September 2017

The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

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22 September 2017

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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22 September 2017

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

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22 September 2017

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

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22 September 2017

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle

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22 September 2017

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22 September 2017

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

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22 September 2017

Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.

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22 September 2017

Co-secretion of amylin and insulin from cultured islet β-cells: Modulation by nutrient secretagogues, islet hormones and hypoglycemic agents

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22 September 2017

Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells

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25 September 2017

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

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25 September 2017

Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport

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AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

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15 June 2018

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15 June 2018

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Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay

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Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo

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20 August 2018

Short-term intermittent exposure to diazoxide improves functional performance of beta-cells in a high-glucose environment

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20 August 2018

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis

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20 August 2018

AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

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20 August 2018

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20 August 2018

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20 August 2018

Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation

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20 August 2018

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20 August 2018

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20 August 2018

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20 August 2018

The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of the obese diabetic. A comparative study of placebo, sulfonylurea and phenformin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction by phenformin of excessive insulin levels after glucose loading in obese and diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Respiratory inhibition and hypoglycemia by biguanides and decamethylenediguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of glibenclamide and metformin (alone or in combination) on insulin release from isolated human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of dimethylbiguanide on glucose tolerance, serum insulin and growth hormone in obese patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of rat pancreatic B-cells by fluorescence-activated cell sorting

1 reference

https://pubmed.ncbi.nlm.nih.gov/17339833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/SJ.BJP.0707189

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26 December 2019

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24 November 2022

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26 December 2019

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26 December 2019

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