Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro (Q40386417)

20 September 2017

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro (English)

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20 September 2017

1

J H Moffitt

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20 September 2017

B A Fielding

2

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20 September 2017

R Evershed

3

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20 September 2017

R Berstan

4

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20 September 2017

J M Currie

5

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20 September 2017

A Clark

6

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20 September 2017

11 August 2005

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48

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9

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20 September 2017

1819-1829

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https://scigraph.springernature.com/pub.10.1007/s00125-005-1861-9

20 September 2017

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https://api.crossref.org/works/10.1007%2FS00125-005-1861-9

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

21 January 2018

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12 December 2020

Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

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12 December 2020

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats

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12 December 2020

A proposed model for the assembly of chylomicrons

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12 December 2020

Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study

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12 December 2020

Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate

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12 December 2020

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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12 December 2020

Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes.

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12 December 2020

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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12 December 2020

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

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12 December 2020

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

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12 December 2020

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

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12 December 2020

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

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12 December 2020

Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal

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12 December 2020

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

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12 December 2020

Milk fat globules: Fatty acid composition, size and in vivo regulation of fat liquidity

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12 December 2020

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

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12 December 2020

Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey

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12 December 2020

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

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12 December 2020

A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction

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12 December 2020

Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.

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12 December 2020

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

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12 December 2020

The effects of glyceride structure on absorption and metabolism

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12 December 2020

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

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12 December 2020

Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion

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12 December 2020

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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12 December 2020

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

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12 December 2020

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition

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12 December 2020

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

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12 December 2020

Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells

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12 December 2020

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli

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12 December 2020

Fatty acid metabolism and insulin secretion in pancreatic beta cells

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12 December 2020

Nile red: a selective fluorescent stain for intracellular lipid droplets

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12 December 2020

Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels

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12 December 2020

The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters.

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12 December 2020

Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans

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12 December 2020

Lipid rafts and signal transduction

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12 December 2020

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

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12 December 2020

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion

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12 December 2020

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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12 December 2020

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

1 reference

12 December 2020

Uncoupling protein 2 and islet function

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12 December 2020

Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells

1 reference

12 December 2020

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

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12 December 2020

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

1 reference

12 December 2020

Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts.

1 reference

12 December 2020

The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction

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12 December 2020

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

1 reference

12 December 2020

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

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12 December 2020

Long-term effects of weight loss on pharmaceutical costs in obese subjects. A report from the SOS intervention study

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12 December 2020

10.1007/S00125-005-1861-9

Identifiers

DOI

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20 September 2017

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