LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. (Q40217824)

18 September 2017

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. (English)

1 reference

18 September 2017

Mikhail V Semenov

1

1 reference

PubMed ID

17052975

18 September 2017

Xi He

series ordinal

2

1 reference

PubMed ID

17052975

18 September 2017

language of work or name

English

0 references

publication date

19 October 2006

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Journal of Biological Chemistry

18 September 2017

9

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based on heuristic

inferred from page(s)

published in

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18 September 2017

281

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18 September 2017

50

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18 September 2017

38276-38284

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A Wnt canon orchestrating osteoblastogenesis

18 September 2017

1 reference

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LRP5 and Wnt signaling: a union made for bone

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21 January 2018

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

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Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

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1 reference

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Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein

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Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

21 January 2018

1 reference

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The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts

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21 January 2018

1 reference

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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1 reference

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High bone density due to a mutation in LDL-receptor-related protein 5

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

21 January 2018

1 reference

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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1 reference

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High bone mass in mice expressing a mutant LRP5 gene

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Bone biomechanical properties in LRP5 mutant mice

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Regulation of osteoblastogenesis and bone mass by Wnt10b

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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Regulation of bone mass by Wnt signaling

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

21 January 2018

1 reference

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Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

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1 reference

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The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

21 January 2018

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 January 2018

1 reference

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

1 reference

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609509200

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

1 reference

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

21 January 2018

1 reference

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 January 2018

1 reference

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Cloning of a novel member of the low-density lipoprotein receptor family

21 January 2018

1 reference

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Functional and structural diversity of the human Dickkopf gene family

21 January 2018

1 reference

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

1 reference

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Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

21 January 2018

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Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

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Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

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Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity

21 January 2018

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21 January 2018

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Wise, a context-dependent activator and inhibitor of Wnt signalling

21 January 2018

1 reference

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Bone mineral density in sclerosteosis; affected individuals and gene carriers

21 January 2018

1 reference

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609509200

21 January 2018

Identifiers

DOI

10.1074/JBC.M609509200

1 reference

18 September 2017

1 reference

PubMed ID

17052975