GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. (Q40226763)

18 September 2017

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing (English)

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11 May 2020

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11 May 2020

Stefan F Lichtenthaler

9

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11 May 2020

author name string

Christine A F von Arnim

1

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11 May 2020

Robert Spoelgen

2

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11 May 2020

Meihua Deng

4

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11 May 2020

Stephanie Courchesne

5

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11 May 2020

Mirjam Koker

6

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11 May 2020

Toshifumi Matsui

7

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11 May 2020

Hisatomo Kowa

8

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11 May 2020

Michael C Irizarry

10

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11 May 2020

Bradley T Hyman

11

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11 May 2020

language of work or name

English

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publication date

1 September 2006

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18 September 2017

Journal of Neuroscience

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11 May 2020

volume

26

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11 May 2020

issue

39

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11 May 2020

page(s)

9913-9922

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

11 May 2020

cites work

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Maturation and pro-peptide cleavage of beta-secretase

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12 December 2020

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

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12 December 2020

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

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12 December 2020

Microtubule-Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Phosphorylation regulates intracellular trafficking of beta-secretase

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12 December 2020

The LDL receptor gene family: (un)expected signal transducers in the brain

1 reference

12 December 2020

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

1 reference

12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

12 December 2020

Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.

1 reference

12 December 2020

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

12 December 2020

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

1 reference

12 December 2020

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

1 reference

12 December 2020

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

12 December 2020

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

1 reference

12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network

1 reference

12 December 2020

Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

1 reference

12 December 2020

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

1 reference

12 December 2020

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

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12 December 2020

Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein

1 reference

12 December 2020

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

1 reference

12 December 2020

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

1 reference

12 December 2020

GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.

1 reference

12 December 2020

The GGA proteins: adaptors on the move

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12 December 2020

Interactions of GGA3 with the ubiquitin sorting machinery

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12 December 2020

GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network

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12 December 2020

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

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12 December 2020

Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein

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12 December 2020

Loss of apolipoprotein E receptor LR11 in Alzheimer disease

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12 December 2020

Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

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12 December 2020

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

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12 December 2020

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

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12 December 2020

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

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12 December 2020

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

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12 December 2020

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

12 December 2020

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

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12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

12 December 2020

LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses

1 reference

12 December 2020

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

1 reference

12 December 2020

Alpha-synuclein and chaperones in dementia with Lewy bodies.

1 reference

12 December 2020

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

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12 December 2020

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

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12 December 2020

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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12 December 2020

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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12 December 2020

Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve

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12 December 2020

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

12 December 2020

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

12 December 2020

Regulation of APP processing. Potential for the therapeutical reduction of brain amyloid burden

1 reference

12 December 2020

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

12 December 2020

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

12 December 2020

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

1 reference

12 December 2020

Real-time quantitative RT-PCR after laser-assisted cell picking

1 reference

12 December 2020

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

12 December 2020

10.1523/JNEUROSCI.2290-06.2006

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674476&resulttype=core&format=json

11 May 2020

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11 May 2020

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