Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha (Q40237912)

18 September 2017

Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha (English)

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18 September 2017

3

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18 September 2017

Tony Ng

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Banafshé Larijani

object named as

Banafshé Larijani

Peter Joseph Jacques Parker

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object named as

Peter J Parker

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author name string

Richard D Byrne

1

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18 September 2017

Erika Rosivatz

2

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18 September 2017

Rudiger Woscholski

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18 September 2017

language of work or name

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30 August 2006

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18 September 2017

9

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based on heuristic

inferred from page(s)

published in

Cellular Signalling

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18 September 2017

19

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18 September 2017

2

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18 September 2017

321-329

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Early kinetics of Ca2+ fluxes and histamine release in rat mast cells stimulated with compound 48/80

18 September 2017

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells

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1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts

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1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Activation of exocytosis by the heterotrimeric G protein Gi3

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1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphorylation and activation of p70s6k by PDK1

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1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Novel function of phosphoinositide 3-kinase in T cell Ca2+ signaling. A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca2+ entry mechanism

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Basic secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and phosphatidylinositol 3-kinase-dependent mechanism

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Changes in polyphosphoinositide metabolism during mediator release from stimulated rat mast cells

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Inhibition of protein kinase C promotes neuronal survival in low potassium through an Akt-dependent pathway

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Bisperoxovanadium compounds are potent PTEN inhibitors.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Dual regulation of platelet protein kinase B

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Stimulation of inositol phosphate production and GTPase activity by compound 48/80 in rat peritoneal mast cells

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

The role of phosphoinositides in mast cell signalling

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Imaging protein kinase Calpha activation in cells

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Calcium influx in Trypanosoma brucei can be induced by amphiphilic peptides and amines.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Redistribution of phospholipid/Ca2+-dependent protein kinase in mast cells activated by various agonists

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Role of translocation in the activation and function of protein kinase B

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

The so-called anticalmodulins fluphenazine, calmidazolium, and compound 48/80 inhibit the Ca2+- transport system of the endoplasmic reticulum

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Phosphoinositide 3-kinase facilitates antigen-stimulated Ca(2+) influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca(2+) entry mechanism

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Compound 4880 is a selective and powerful inhibitor of calmodulin-regulated functions

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELLSIG.2006.07.004

Identifiers

DOI

10.1016/J.CELLSIG.2006.07.004

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18 September 2017

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