Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans (Q40262182)

19 September 2017

Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans (English)

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ubiquitin-proteasome system

19 September 2017

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Caenorhabditis elegans

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Ataxin-3 homolog CELE_F28F8.6

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GOA release 2020-03-11

Peter O Bauer

2

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Bernhard Landwehrmeyer

object named as

Bernhard G Landwehrmeyer

5

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author name string

Liakot A Khan

1

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19 September 2017

Haruko Miyazaki

3

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19 September 2017

Katrin S Lindenberg

4

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19 September 2017

Nobuyuki Nukina

6

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19 September 2017

language of work or name

English

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publication date

1 July 2006

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Journal of Neurochemistry

19 September 2017

12

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based on heuristic

inferred from page(s)

published in

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19 September 2017

98

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19 September 2017

2

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19 September 2017

576-587

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

19 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Diseases of unstable repeat expansion: mechanisms and common principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Inefficient degradation of truncated polyglutamine proteins by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Oxidative stress induces axonal beading in cultured human brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Machado-Joseph disease: an autosomal dominant motor system degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03895.X

10.1111/J.1471-4159.2006.03895.X

21 January 2018

Identifiers

DOI

1 reference

19 September 2017

1 reference