Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins (Q44833524)

6 December 2017

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins (English)

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6 December 2017

Prasanna Venkatraman

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6 December 2017

Ronald Wetzel

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6 December 2017

Motomasa Tanaka

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6 December 2017

Nobuyuki Nukina

4

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6 December 2017

Alfred L Goldberg

5

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6 December 2017

language of work or name

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1 April 2004

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6 December 2017

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6 December 2017

14

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6 December 2017

1

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6 December 2017

95-104

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Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum

6 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Random coil conformation for extended polyglutamine stretches in aqueous soluble monomeric peptides.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Solubilization and disaggregation of polyglutamine peptides

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Are Huntington's and polyglutamine-based ataxias proteasome storage diseases?

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Protein degradation and protection against misfolded or damaged proteins

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

A gated channel into the proteasome core particle

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Transferring substrates to the 26S proteasome.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Photometric analysis of proteins and peptides at 191–194 mμ

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Structural basis for the activation of 20S proteasomes by 11S regulators

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

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https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

Glutamine repeats and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900151-0

7 January 2021

10.1016/S1097-2765(04)00151-0

Identifiers

DOI

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6 December 2017

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