Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome (Q40289618)

19 September 2017

title

Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome (English)

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acute megakaryoblastic leukemia

19 September 2017

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Xu G

1

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19 September 2017

Kanezaki R

2

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19 September 2017

Toki T

3

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19 September 2017

Watanabe S

4

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19 September 2017

Takahashi Y

5

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19 September 2017

Terui K

6

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19 September 2017

Kitabayashi I

7

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19 September 2017

Ito E

8

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19 September 2017

language of work or name

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1 June 2006

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19 September 2017

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19 September 2017

volume

20

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19 September 2017

issue

6

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19 September 2017

page(s)

1002-1008

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The management of neoplastic disorders of haematopoiesis in children with Down's syndrome

19 September 2017

cites work

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GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome

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Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

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Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder

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Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

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A leukemogenic twist for GATA1.

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Core-binding factors in haematopoiesis and leukaemia

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

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RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

21 January 2018

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Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.

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Origins of leukaemia in children with Down syndrome

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Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis

21 January 2018

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The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

21 January 2018

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Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibα Gene

21 January 2018

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Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia

21 January 2018

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Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

21 January 2018

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Functional characterization of the two alternative promoters of human p45 NF-E2 gene

21 January 2018

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Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform

21 January 2018

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Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding

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The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.

21 January 2018

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Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development

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Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

21 January 2018

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Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis

21 January 2018

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A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction

21 January 2018

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GATA1 function, a paradigm for transcription factors in hematopoiesis

21 January 2018

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A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon

21 January 2018

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Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

21 January 2018

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p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes

21 January 2018

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Activation of the megakaryocyte-specific gene platelet basic protein (PBP) by the Ets family factor PU.1.

21 January 2018

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Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2404223

1 reference

Dimensions Publication ID

19 September 2017

1039212182

0 references

1 reference