Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism (Q40293299)

19 September 2017

Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism (English)

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19 September 2017

Bettina Proneth

1

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19 September 2017

Zhimin Xiang

2

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19 September 2017

Irina D Pogozheva

3

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19 September 2017

Sally A Litherland

4

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19 September 2017

Oleg S Gorbatyuk

5

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19 September 2017

Amanda M Shaw

6

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19 September 2017

William J Millard

7

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19 September 2017

Henry I Mosberg

8

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19 September 2017

Carrie Haskell-Luevano

9

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19 September 2017

1 March 2006

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Chemical Biology and Drug Design

19 September 2017

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19 September 2017

67

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19 September 2017

3

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19 September 2017

215-229

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Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.

19 September 2017

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https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Molecular cloning, expression, and characterization of a fifth melanocortin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

A frameshift mutation in MC4R associated with dominantly inherited human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

A frameshift mutation in human MC4R is associated with a dominant form of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

pA, a new scale for the measurement of drug antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Characterization of Agouti-related protein binding to melanocortin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Nonlinear regression using spreadsheets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Structure of bovine rhodopsin in a trigonal crystal form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Activation of rhodopsin: new insights from structural and biochemical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Receptor activation: what does the rhodopsin structure tell us?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Structural basis for activation of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2006.00362.X

10.1111/J.1747-0285.2006.00362.X

21 January 2018

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DOI

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19 September 2017

1 reference