WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. (Q40323754)

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16 January 2020

title

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization (English)

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16 January 2020

main subject

BCL2 apoptosis regulator

1 reference

DNA-binding transcription factor binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Petr Pancoska

9

1 reference

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16 January 2020

author name string

York Tomita

1

1 reference

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16 January 2020

Natasha Marchenko

2

1 reference

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16 January 2020

Susan Erster

3

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16 January 2020

Alice Nemajerova

4

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16 January 2020

Alexander Dehner

5

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16 January 2020

Christian Klein

6

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16 January 2020

Hongguang Pan

7

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16 January 2020

Horst Kessler

8

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16 January 2020

Ute M Moll

10

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16 January 2020

language of work or name

English

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publication date

26 January 2006

1 reference

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Journal of Biological Chemistry

16 January 2020

published in

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16 January 2020

volume

281

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16 January 2020

issue

13

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16 January 2020

page(s)

8600-8606

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Live or let die: the cell's response to p53

16 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Overexpression of the Bcl-2 protein increases the half-life of p21Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Stress-induced p53 runs a transcription-independent death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Senescence, apoptosis and therapy--cutting the lifelines of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Senescent cells are resistant to death despite low Bcl-2 level

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

p53 and bcl-2 protein expression in non-small-cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

Solution structure of the antiapoptotic protein bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507611200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507611200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16443602%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference