Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function (Q40324361)

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scientific article published on 27 January 2006

Language	Label	Description	Also known as
English	Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function	scientific article published on 27 January 2006

Statements

scholarly article

1 reference

Europe PubMed Central

19 September 2017

Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function (English)

1 reference

Europe PubMed Central

19 September 2017

1 reference

based on heuristic

inferred from title

Caroline T Bonner

object named as

C Bonner

2

0 references

author name string

H Wobser

1

1 reference

Europe PubMed Central

19 September 2017

J J Nolan

3

1 reference

Europe PubMed Central

19 September 2017

M M Byrne

4

1 reference

Europe PubMed Central

19 September 2017

J H M Prehn

5

1 reference

Europe PubMed Central

19 September 2017

publication date

27 January 2006

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

49

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Europe PubMed Central

19 September 2017

3

1 reference

Europe PubMed Central

19 September 2017

519-526

1 reference

Europe PubMed Central

19 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-005-0119-x

0 references

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2 family: regulators of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin feedback action on pancreatic beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic, metabolic and clinical characteristics of maturity onset diabetes of the young.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The promoter of the salmon insulin-like growth factor I gene is activated by hepatocyte nuclear factor 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte Growth Factor Preserves Beta Cell Mass and Mitigates Hyperglycemia in Streptozotocin-induced Diabetic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine regulation of single pancreatic beta-cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of translocation in the activation and function of protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16440211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-005-0119-X

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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