Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. (Q47858013)

6 February 2018

title

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. (English)

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6 February 2018

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3

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Per-Olof Berggren

series ordinal

4

object named as

Berggren PO

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6 February 2018

author name string

Leibiger IB

series ordinal

1

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6 February 2018

Leibiger B

series ordinal

2

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publication date

1 May 1998

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6 February 2018

published in

Molecular Cell

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6 February 2018

volume

1

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6 February 2018

page(s)

933-938

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6 February 2018

issue

6

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6 February 2018

Mechanism of activation of protein kinase B by insulin and IGF-1

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The insulin gene contains multiple transcriptional elements that respond to glucose

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The insulin gene promoter. A simplified nomenclature.

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Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells

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A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer

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Insulin signal transduction and the IRS proteins

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Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

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Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression

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Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression

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The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.

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Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets

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Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose.

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Multiple independent inputs are required for activation of the p70 S6 kinase

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7 January 2021

10.1016/S1097-2765(00)80093-3

Identifiers

DOI

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6 February 2018

PubMed ID

9660977

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6 February 2018