The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants. (Q40328635)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417523%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417523%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

main subject

transmembrane protein

0 references

0 references

1

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15 January 2020

author name string

M Claire Bartlett

series ordinal

2

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15 January 2020

Ying Wang

series ordinal

3

1 reference

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15 January 2020

David M Clarke

series ordinal

4

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15 January 2020

language of work or name

English

0 references

publication date

1 May 2006

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15 January 2020

number of pages

6

1 reference

inferred from page(s)

published in

Biochemical Journal

1 reference

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15 January 2020

volume

395

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15 January 2020

issue

3

1 reference

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15 January 2020

page(s)

537-542

1 reference

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Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound

15 January 2020

cites work

1 reference

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Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex

22 September 2017

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The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator

22 September 2017

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Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains.

22 September 2017

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Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

22 September 2017

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Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein

22 September 2017

1 reference

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Degradation of CFTR by the ubiquitin-proteasome pathway

22 September 2017

1 reference

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Hypothesis about the function of membrane-buried proline residues in transport proteins

22 September 2017

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

22 September 2017

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Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

22 September 2017

1 reference

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Asymmetric structure of the cystic fibrosis transmembrane conductance regulator chloride channel pore suggested by mutagenesis of the twelfth transmembrane region

25 September 2017

1 reference

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Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited

25 September 2017

1 reference

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

25 September 2017

1 reference

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Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462697

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

25 September 2017

1 reference

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An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator

25 September 2017

1 reference

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Disease-associated mutations in the fourth cytoplasmic loop of cystic fibrosis transmembrane conductance regulator compromise biosynthetic processing and chloride channel activity.

17 June 2018

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Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

17 June 2018

1 reference

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462697

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462697

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

17 June 2018

1 reference

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Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

17 June 2018

1 reference

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Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16417523

12 December 2020

inferred from PubMed ID database lookup

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16417523

12 December 2020

inferred from PubMed ID database lookup

The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16417523

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1042/BJ20060013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417523%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16417523%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference