C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation (Q40348234)

19 September 2017

title

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation (English)

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19 September 2017

Dirk Beher

2

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Alison Goate

object named as

Alison Goate

6

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author name string

Jun Wang

1

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19 September 2017

Andrew C Nyborg

3

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19 September 2017

Mark S Shearman

4

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19 September 2017

Todd E Golde

5

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19 September 2017

language of work or name

English

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publication date

23 November 2005

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Journal of Neurochemistry

19 September 2017

published in

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19 September 2017

volume

96

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19 September 2017

issue

1

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19 September 2017

page(s)

218-227

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In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities.

21 January 2018

1 reference

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Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 January 2018

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Novel presenilin 1 mutations associated with early onset of dementia in a family with both early-onset and late-onset Alzheimer disease

21 January 2018

1 reference

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The presenilins turned inside out: implications for their structures and functions

21 January 2018

1 reference

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

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Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

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Novel class of polytopic proteins with domains associated with putative protease activity

21 January 2018

1 reference

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

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The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

A nine-transmembrane domain topology for presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

1 reference

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Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

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Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

1 reference

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Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

21 January 2018

1 reference

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A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

21 January 2018

1 reference

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03548.X

10.1111/J.1471-4159.2005.03548.X

21 January 2018

Identifiers

DOI

1 reference

19 September 2017

1 reference