Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells (Q40352211)

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scientific article published on 11 November 2005

Language	Label	Description	Also known as
English	Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells	scientific article published on 11 November 2005

Statements

scholarly article

1 reference

Europe PubMed Central

19 September 2017

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells (English)

1 reference

Europe PubMed Central

19 September 2017

Nils Billestrup

6

1 reference

Europe PubMed Central

19 September 2017

Joachim Størling

object named as

J Størling

2

0 references

Thomas Mandrup-Poulsen

object named as

T Mandrup-Poulsen

7

0 references

author name string

L Larsen

1

1 reference

Europe PubMed Central

19 September 2017

M Darville

3

1 reference

Europe PubMed Central

19 September 2017

D L Eizirik

4

1 reference

Europe PubMed Central

19 September 2017

C Bonny

5

1 reference

Europe PubMed Central

19 September 2017

publication date

11 November 2005

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

48

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Europe PubMed Central

19 September 2017

12

1 reference

Europe PubMed Central

19 September 2017

2582-2590

1 reference

Europe PubMed Central

19 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-005-0039-9

0 references

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

1 reference

https://api.crossref.org/works/10.1007%2FS00125-005-0039-9

21 January 2018

Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import

1 reference

https://api.crossref.org/works/10.1007%2FS00125-005-0039-9

21 January 2018

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of transcription factor function by phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-cell apoptosis: stimuli and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IB1 reduces cytokine-induced apoptosis of insulin-secreting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta cell death and protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Casein kinase II-mediated phosphorylation of NF-kappaB p65 subunit enhances inducible nitric-oxide synthase gene transcription in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinction between interleukin-1-induced necrosis and apoptosis of islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and characterization of the rat inducible nitric oxide synthase (iNOS) gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity in control of mRNA stability by AU-rich elements.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16283237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-005-0039-9

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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