MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. (Q40362823)

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8 January 2020

MDMA

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title

MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220332%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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Gregory M Miller

2

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8 January 2020

publication date

12 October 2005

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8 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220332%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

189

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220332%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

issue

4

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8 January 2020

page(s)

489-503

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MDMA. The dark side of ecstasy

8 January 2020

cites work

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The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine

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Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants

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Molecular cloning, expression and characterization of a bovine serotonin transporter

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Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain

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Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain

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Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate.

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Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin

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Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate

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12 December 2020

Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function

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12 December 2020

Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity

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Paroxetine inhibits acute effects of 3,4-methylenedioxymethamphetamine on the immune system in humans.

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12 December 2020

Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor

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'Is MDMA a human neurotoxin?': diverse views from the discussants

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MDMA induced dopamine release in vivo: role of endogenous serotonin

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Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.

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Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine

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Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.

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12 December 2020

Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB

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Monoamine transporters and psychostimulant drugs

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12 December 2020

The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoaminergic neurotransmission in the central nervous system

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Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery

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12 December 2020

Changes in serotonin, dopamine and noradrenaline levels in striatum and nucleus accumbens after repeated administration of the abused drug MDMA in rats

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12 December 2020

Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA).

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12 December 2020

MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys

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12 December 2020

Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.

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12 December 2020

Psychedelic drugs: the ups and downs of ecstasy

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12 December 2020

'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA

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12 December 2020

MDMA transiently alters biogenic amines and metabolites in mouse brain and heart.

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The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

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Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations

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12 December 2020

The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release

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Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity

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Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes

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Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices

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Intrasynaptosomal sequestration of [3H]amphetamine and [3H]methylenedioxyamphetamine: characterization suggests the presence of a factor responsible for maintaining sequestration.

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12 December 2020

Absolute configuration and psychotomimetic activity

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12 December 2020

Characterization of a recombinant human dopamine transporter in multiple cell lines

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12 December 2020

Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram

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12 December 2020

[3H]3,4-methylenedioxymethamphetamine (MDMA) interactions with brain membranes and glass fiber filter paper

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12 December 2020

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine

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12 December 2020

Primate trace amine receptor 1 modulation by the dopamine transporter.

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12 December 2020

'Ecstasy' and intracerebral haemorrhage

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12 December 2020

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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12 December 2020

Investigation of the prejunctional alpha2-adrenoceptor mediated actions of MDMA in rat atrium and vas deferens

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12 December 2020

Trace amines: identification of a family of mammalian G protein-coupled receptors

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12 December 2020

Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research

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Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen

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Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge

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12 December 2020

The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain

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12 December 2020

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

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12 December 2020

Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine

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12 December 2020

Amphetamine neurotoxicity: accomplishments and remaining challenges

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12 December 2020

Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse

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12 December 2020

Neurotoxic amphetamine analogues: effects in monkeys and implications for humans

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12 December 2020

Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

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12 December 2020

Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type

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12 December 2020

Interactions of methylenedioxymethamphetamine with monoamine transmitter release mechanisms in rat brain slices

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12 December 2020

Evidence for specific methylenedioxymethamphetamine (ecstasy) binding sites in the rat brain

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12 December 2020

Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.

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12 December 2020

How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy?

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12 December 2020

Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants.

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12 December 2020

Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors

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12 December 2020

[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues

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12 December 2020

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans

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12 December 2020

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

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12 December 2020

Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

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Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters. Evidence for localization in lipid rafts and lipid raft-mediated internalization

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12 December 2020

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux

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12 December 2020

The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells.

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12 December 2020

Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?

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12 December 2020

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

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12 December 2020

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

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12 December 2020

Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

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12 December 2020

Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging

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12 December 2020

Sympathomimetic actions of methylenedioxymethamphetamine in rat and rabbit isolated cardiovascular tissues

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12 December 2020

A voxel-based PET investigation of the long-term effects of "Ecstasy" consumption on brain serotonin transporters.

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12 December 2020

The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats

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12 December 2020

Characterization of brain interactions with methylenedioxyamphetamine and methylenedioxymethamphetamine

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12 December 2020

Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.

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12 December 2020

Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

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12 December 2020

Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions.

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12 December 2020

Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model.

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12 December 2020

Dopamine transporter-dependent induction of C-Fos in HEK cells

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12 December 2020

Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats

1 reference

12 December 2020

Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations

1 reference

12 December 2020

(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates

1 reference

12 December 2020

Phosphorylation and regulation of antidepressant-sensitive serotonin transporters

1 reference

12 December 2020

10.1007/S00213-005-0174-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220332%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 January 2020

1041787547

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